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CR-1305

Development stage: Preclinical
Lead developer: Coeurative
Modality: Small Molecules
Administration: Intravenous

Overview

CR-1305 is a preclinical-stage small molecule therapeutic candidate being developed by **Coeurative**. It is specifically formulated for **intravenous (IV)** administration to facilitate the **immediate dilation** of coronary arteries, aimed at providing rapid relief for **anginal pain** in patients with **coronary artery disease**. CR-1305 is part of a suite of vasodilatory candidates from Coeurative, which also includes the oral formulation CR-0305. As of the current pipeline status, CR-1305 is categorized as a future planned trial with no first-in-human (FIH) date yet established.

Targets

UGT1A10 (UDP-glucuronosyltransferase family 1 member A10)ERN1 (Inositol-requiring enzyme 1 alpha)CYP3A4 (Cytochrome P450 3A4)TOP2A (DNA topoisomerase II)TUBB (Tubulin (alpha and beta subunits))CYP1A2 (Cytochrome P450 1A2)DNA

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