CR-PEG-GBP

CR-PEG-GBP is an investigational, pH-sensitive theranostic nanoprobe developed by the Shenzhen University Health Science Center for the targeted imaging and treatment of hepatocellular carcinoma (HCC). The molecule is a peptide-drug conjugate (PDC) consisting of a near-infrared-II (NIR-II) croconaine dye (CR) linked to a Glypican-3 (GPC3) binding peptide (GBP) via a polyethylene glycol (PEG) spacer. Engineered for intelligent delivery, the conjugate remains as small nanoprobes (<20 nm) at physiological pH but undergoes in situ self-assembly into larger nanoparticles (>160 nm) within the acidic tumor microenvironment (pH ~6.5). This aggregation enhances tumor accumulation and retention while allowing for excretion from normal tissues. As a theranostic agent, it enables dual-modal NIR-II fluorescence and photoacoustic (PA) imaging for precise tumor localization. Furthermore, the croconaine core facilitates dual-modal therapy; upon activation by light or ultrasound, it mediates photothermal therapy (PTT) and sonodynamic therapy (SDT), respectively, generating heat and reactive oxygen species to induce targeted tumor ablation.

Other names

gabapentin-Shenzhen University Health Science Center-Glypican-3-Nanoparticle-Peptide-drug conjugate-Theranostic-Intravenous-Hepatocellular carcinomaCroconaine-PEG-GPC3 binding peptide conjugateCroconaine-PEG-GPC-3 binding peptide conjugateCroconaine-PEG-GPC 3 binding peptide conjugate