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Crampamine
- Development stage
- Unknown
- Lead developer
- TRP Company
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Crampamine is a multi-ingredient dietary supplement formulated to alleviate and prevent muscle cramps, particularly nocturnal leg cramps and spasms. The formulation combines essential nutrients—magnesium gluconate, vitamin B6 (pyridoxine), and vitamin E (alpha-tocopherol)—with botanical extracts including Cramp Bark (Viburnum opulus) and the flavonoid rutin. Magnesium serves as a physiological calcium antagonist and N-methyl-D-aspartate (NMDA) receptor blocker, promoting muscle relaxation by modulating neuromuscular excitability. Vitamin B6 is included to enhance the cellular uptake of magnesium, while Vitamin E and rutin provide antioxidant support and improve peripheral vascular health. Cramp Bark has traditionally been used for its antispasmodic properties, potentially acting through the inhibition of smooth and skeletal muscle contractions. The product is marketed for individuals experiencing muscle spasms, stiffness, and exercise-related cramping.
- Brand names
- Crampamine
02
Targets
CaV (Voltage-gated calcium channel protein complex)NMDAR (Glutamate receptor ionotropic, NMDA)
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