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Cranberry juice and cranberry powder capsules are natural products being investigated by the Medical University of South Carolina (MUSC) for their potential to interact with conventional medications. In a Phase 1 clinical trial (NCT00200759), researchers evaluated how these cranberry products affect the activity of cytochrome P450 (CYP) enzymes, particularly CYP3A4, which are responsible for the metabolism of many drugs. The study also aimed to determine the bioavailability of cranberry-derived phytochemicals, such as flavonoids, anthocyanins, and triterpenes, in healthy volunteers. While cranberry is traditionally used for the prevention of urinary tract infections, this specific research focuses on its pharmacokinetic profile and safety when co-administered with other pharmaceuticals.
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