Drug intelligence / Profile preview

crassocephalum rabens extract

Development stage
Unknown
Lead developer
Greenyn Biotechnology
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Crassocephalum rabens extract is a botanical extract derived from the aerial parts of the herb Crassocephalum rabens, traditionally used in Taiwanese folk medicine to treat inflammation-related conditions.[2][1] The extract contains a prominent active phytogalactolipid, 1,2-di-O-linolenoyl-3-O-β-galactopyranosyl-sn-glycerol (dLGG), which has demonstrated anti-oxidative, anti-inflammatory, anti-hyaluronidase, and anti-cancer activities in preclinical studies. Clinical studies suggest that this extract may improve skin health by increasing collagen content, improving skin elasticity and brightness, and reducing wrinkles and UV spots in healthy adults.[1][2] The mechanism of action is believed to involve inhibition of cyclooxygenase-2 (COX-2) expression and matrix metalloproteinases (MMPs), leading to reduced melanin production and decreased collagen degradation.[1] It is being developed and marketed as a dietary supplement for skin aging, vitality, and physical strength, and has been researched for possible anti-cancer effects, including potential utility in breast cancer/metastasis.[1][2][4][3]

Brand names
RabenWhiteRabenLiv
Other names
Zhaohe CaoShowa grass extract
02

Targets

HYAL (Hyaluronidase family (HYAL))NOS2 (Nitric Oxide Synthase 2)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TYR (Tyrosinase)MMP12 (Macrophage Metalloelastase)

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