Drug intelligence / Profile preview

Crataegus gracilior petroleum ether extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Crataegus gracilior petroleum ether extract is a research-stage botanical extract derived from the stems and leaves of Mexican hawthorn (*Crataegus gracilior* J. B. Phipps). Unlike other hawthorn species whose antitumor activity resides in polar extracts, the petroleum ether fraction of *C. gracilior* uniquely exhibits cytotoxic properties against breast cancer cells, inducing cell death via apoptosis. The active compounds identified in this extract are β-sitosterol and tocopherol, whose combined activity is believed to drive its cytotoxic and pro-apoptotic effects.

Other names
Crataegus gracilior petroleum ether fractionMexican hawthorn petroleum ether extractpetroleum ether extract of Crataegus gracilior

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