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CRB2104
- Development stage
- Preclinical
- Lead developer
- Biocytogen
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Subcutaneous
01
Overview
CRB2104 is a preclinical-stage, bispecific T-cell engager (TCE) designed with a 2:1 format featuring bivalent high-affinity arms targeting anti-Müllerian hormone receptor type 2 (AMHR2) and an affinity-optimized CD3-binding arm. Developed by Biocytogen and China Resources Angde Biopharmaceutical, CRB2104 is designed to treat AMHR2-positive solid tumors, such as epithelial ovarian cancer and colorectal cancer, by inducing potent tumor-specific T-cell-mediated cytotoxicity while minimizing the risk of cytokine release syndrome (CRS).
02
Targets
CD3 (T-cell surface glycoprotein CD3)AMHR2 (Anti-Müllerian hormone receptor type 2)FCGRT (Neonatal crystallizable fragment receptor)
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