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CRCHUM-MT cocktail
- Development stage
- Unknown
- Lead developer
- CHUM Research Centre
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Intramuscular
01
Overview
The CRCHUM-MT cocktail is a CYP450 probe drug cocktail used in clinical research to evaluate the activity of seven major CYP450 drug-metabolizing enzymes. It consists of caffeine (CYP1A2), bupropion (CYP2B6), tolbutamide (CYP2C9), omeprazole (CYP2C19), dextromethorphan (CYP2D6), and midazolam (CYP3As), with chlorzoxazone (CYP2E1) administered separately. This cocktail is primarily used in research settings to assess how various conditions, such as type 2 diabetes mellitus, affect drug metabolism.
- Other names
- CRCHUM-MT probe drug cocktail
02
Targets
CYP2C19 (Cytochrome P450 2C19)CYP1A2 (Cytochrome P450 1A2)CYP3A4 (Cytochrome P450 3A4)CYP2B6 (Cytochrome P450 2B6)CYP2E1CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)CYP3A5 (Cytochrome P450 family 3 subfamily A member 5)
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