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This combination nutritional supplement intervention consists of **creatine monohydrate** and **conjugated linoleic acid (CLA)**. It was evaluated in a randomized, double-blind, placebo-controlled clinical trial (NCT00473902) as an adjunct to resistance exercise training for the treatment of **sarcopenia** in older adults. Creatine monohydrate acts by increasing intramuscular phosphocreatine stores, which facilitates the rapid regeneration of ATP during high-intensity muscle contraction, thereby enhancing strength and lean mass gains. Conjugated linoleic acid is a group of fatty acid isomers that may improve body composition by reducing fat mass and potentially increasing fat-free mass through the modulation of lipid metabolism and inflammatory pathways. The study, led by researchers at **McMaster University** and **Hamilton Health Sciences Corporation**, demonstrated that the combination could enhance the beneficial effects of resistance training on strength and body composition in individuals over 65 years of age.
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