Drug intelligence / Profile preview

creatine monohydrate + conjugated linoleic acid

Development stage
Unknown
Lead developer
McMaster University
Modality
Small Molecules
Administration
Oral
01

Overview

This combination nutritional supplement intervention consists of **creatine monohydrate** and **conjugated linoleic acid (CLA)**. It was evaluated in a randomized, double-blind, placebo-controlled clinical trial (NCT00473902) as an adjunct to resistance exercise training for the treatment of **sarcopenia** in older adults. Creatine monohydrate acts by increasing intramuscular phosphocreatine stores, which facilitates the rapid regeneration of ATP during high-intensity muscle contraction, thereby enhancing strength and lean mass gains. Conjugated linoleic acid is a group of fatty acid isomers that may improve body composition by reducing fat mass and potentially increasing fat-free mass through the modulation of lipid metabolism and inflammatory pathways. The study, led by researchers at **McMaster University** and **Hamilton Health Sciences Corporation**, demonstrated that the combination could enhance the beneficial effects of resistance training on strength and body composition in individuals over 65 years of age.

Other names
creatine + CLACrM + CLA
02

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)PPARA (Peroxisome proliferator-activated receptor alpha)

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