Drug intelligence / Profile preview

Cresorol

Development stage
Preclinical
Lead developer
Flavocure Biotech
Modality
Small Molecules
01

Overview

Cresorol is a cannabis-derived small molecule flavonoid developed by Flavocure Biotech for the treatment of Acute Myeloid Leukemia (AML). It functions as a FLT3 inhibitor, demonstrating potent activity against wild-type FLT3 as well as clinically relevant mutations including FLT3-ITD and FLT3-D835Y. Additionally, the molecule exhibits moderate inhibitory activity against the CSF1R kinase. Cresorol has been granted Orphan Drug Designation by the FDA for the treatment of AML. It is currently in pre-clinical development, with plans to advance into Phase 1 clinical trials following the completion of toxicology studies.

Other names
chrysoeriol
02

Targets

FLT3 (Fms related receptor tyrosine kinase 3)CSF1R (Macrophage colony-stimulating factor receptor)

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