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Crest Toothpaste is a **non-specific Procter & Gamble OTC fluoride-dentifrice brand family**, rather than one chemically uniform drug product. Crest formulations include sodium fluoride anticavity toothpastes and stannous fluoride anticavity and antigingivitis toothpastes; the exact active ingredient, concentration, labeled indications, and ancillary ingredients vary by named Crest variant. Fluoride acts locally on tooth enamel to reduce acid-mediated demineralization and promote remineralization, thereby preventing dental caries. Stannous fluoride-containing variants additionally provide antibacterial plaque and gingivitis benefits and may help reduce dentin hypersensitivity and acid erosion. Crest originated from Procter & Gamble research conducted with Indiana University and was introduced in 1955. ([us.pg.com](https://us.pg.com/pg-history/))
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