Drug intelligence / Profile preview

CrF-ADSC-exo

Development stage: Preclinical
Lead developer: Shanghai Tenth People's Hospital
Modality: Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration: Parenteral

Overview

CrF-ADSC-exo refers to exosomes derived from adipose-derived stem cells (ADSCs) isolated from creeping fat (CrF), a characteristic pathological feature of Crohn's disease. These exosomes are enriched with miR-132-3p, which targets the RASA1/ERK1/2 signaling pathway in lymphatic endothelial cells. By modulating this axis, CrF-ADSC-exo promotes lymphangiogenesis and improves lymphatic drainage, thereby alleviating inflammation in experimental models of colitis and mesenteritis. This research, primarily conducted at Shanghai Tenth People's Hospital, suggests a potential therapeutic role for these exosomes in treating the mesenteric and intestinal complications of Crohn's disease.

Other names: creeping fat-derived adipose stem cell exosomesCrF-ADSC-derived exosomes

Targets

MAPK3 (Mitogen-activated protein kinase 1)RASA1 (p120 RasGAP)

Beyond the preview

Go deeper on CrF-ADSC-exo.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on CrF-ADSC-exo.

Explore the full profile