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cRGD-ZW800-1

Development stage: Phase 2
Lead developer: Curadel
Modality: Peptide-Drug Conjugates → Peptide Conjugates → Peptides
Administration: Intravenous

Overview

cRGD-ZW800-1 is a zwitterionic near-infrared fluorescent peptide used as an imaging agent for cancer detection during surgery. It consists of a cyclic pentapeptide (cRGD) conjugated to the 800 nm NIR fluorophore ZW800-1. The cRGD moiety selectively binds to various integrins (including αVβ3, αVβ5) which are overexpressed on malignant cells and neoangiogenic vasculature. This binding allows real-time visualization of tumors during surgical procedures. The zwitterionic chemical structure and neutral charge of the compound reduce nonspecific uptake and background fluorescent signals, enhancing tumor-to-background contrast. The agent is rapidly eliminated through the kidneys after intravenous administration.

Other names: cyclo-(RGDyK)-ZW800-1

Targets

αVβ3 (Integrin αVβ3)αVβ5 (Integrin αVβ5)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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