CRISPR-Cas9 CXCL10 knockout

CRISPR-Cas9 CXCL10 knockout refers to the targeted genetic deletion of the C-X-C motif chemokine ligand 10 (CXCL10) gene using the CRISPR-Cas9 gene-editing system. In the context of T-cell acute lymphoblastic leukemia (T-ALL) research, this modification is employed to investigate the role of the CXCR3/CXCL10 signaling axis in central nervous system (CNS) and meningeal infiltration. CXCL10 is primarily expressed by meningeal stromal cells in response to inflammatory cytokines (such as IFN-gamma and TNF) produced by infiltrating T-ALL cells. By knocking out CXCL10 in stromal cells or utilizing CXCL10-deficient mouse models, researchers have demonstrated a significant reduction in leukemic cell adhesion and migration to the meninges. This suggests that targeting the CXCL10 chemokine or its receptor, CXCR3, could be a viable therapeutic strategy to prevent or treat CNS involvement and relapse in T-ALL patients.

Other names

CXCL10 knockoutCXCL-10 knockoutCXCL 10 knockoutCXCL10 KOCXCL-10 KOCXCL 10 KO