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CRNDE short hairpin RNA
- Development stage
- Preclinical
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Ex Vivo, Intravenous, Intratumoral
01
Overview
CRNDE short hairpin RNA (sh-CRNDE) is an experimental RNA interference (RNAi) agent designed to silence the expression of the long non-coding RNA (lncRNA) Colorectal Neoplasia Differentially Expressed (CRNDE). In preclinical models of ovarian cancer, CRNDE has been identified as a driver of cisplatin resistance by modulating the SRSF1/TIA1 signaling pathway. By utilizing shRNA to knock down CRNDE levels, researchers have demonstrated increased sensitivity to cisplatin and reduced tumor growth in vitro and in vivo. This agent is primarily used as a research tool to explore the functional role of lncRNAs in chemoresistant malignancies and to validate CRNDE as a potential therapeutic target.
- Other names
- sh-CRNDEshRNA-CRNDEshort hairpin RNA targeting CRNDE
02
Targets
CRNDE (Colorectal neoplasia differentially expressed)
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