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cross-linked sodium hyaluronate + lidocaine
- Development stage
- Unknown
- Lead developer
- Keyan Biotechnology
- Modality
- Small Molecules
- Administration
- Injection, Intraarticular, Subcutaneous, Intracutaneous, Topical (for Representative Formulations)
01
Overview
A **combination** of cross-linked sodium hyaluronate (hyaluronic acid) and lidocaine used primarily as an injectable dermal filler or for intra-articular use in aesthetic medicine and pain management. Cross-linked sodium hyaluronate serves as a long-lasting, viscoelastic carrier and space-filling agent, providing structural support and hydration due to its high water retention and biocompatibility. Lidocaine is a local anesthetic that reduces pain and discomfort at the injection site by stabilizing neuronal membranes and inhibiting nerve impulse conduction. The combination allows for both cosmetic (e.g., wrinkle filling, facial contouring) and joint-related (e.g., osteoarthritis) applications, offering a balance of immediate anesthetic relief and prolonged physical effect due to the cross-linked hyaluronate matrix[1][4][6].
- Brand names
- Restylane Silk
- Other names
- cross-linked hyaluronic acid + lidocainecross-linked hyaluronate + lidocainecross-linked HA + lidocaineHAL (hyaluronic acid plus lidocaine)
02
Targets
SCN5A (Sodium channel protein type 5 subunit alpha)SCN4A (Voltage-gated sodium channel protein type 4 subunit alpha)
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