crotonoside

Crotonoside is a naturally occurring nucleoside analogue, specifically an isoguanosine derivative, originally isolated from the seeds of *Croton tiglium* L. It is currently being investigated for its potential as an anti-leukemic agent, particularly in acute myeloid leukemia (AML). Crotonoside exerts its effects through multiple mechanisms, including the inhibition of FLT3 activation, reduction of HDAC3 and HDAC6 expression, and downregulation of APOBEC3G. It also disrupts DNA synthesis and causes mitochondrial dysfunction by inhibiting mitochondrial DNA polymerase γ, leading to the accumulation of reactive oxygen species (ROS) and the induction of ferroptosis via the p62/KEAP1 autophagy pathway. Historically, crotonoside has been recognized as a bioactive component in traditional medicine for treating conditions such as constipation, inflammation, and rheumatism.

Other names

isoguanosine2-hydroxyadenosine