CRST-1

**CRST-1** is an unmarketed, preclinical cancer-treatment adjunct described by GRDG Sciences as a natural-product-derived medical-food and probe-molecule program intended to accompany conventional anticancer therapies. In cell phosphorylation assays, it inhibited serine/threonine-protein kinase Pim-1 and serine/threonine-protein kinase Pim-3, with reported IC50 values of 0.00014 M and 0.00018 M, respectively. Its precise chemical composition, dosage form, route, and relationship to the separately described Linebacker compounds have not been publicly established. ([prnewswire.com](https://www.prnewswire.com/news-releases/grdg-sciences-announces-preclinical-success-of-crst-1-medical-food-as-a-pim-inhibitor-301191220.html))