Drug intelligence / Profile preview

CS5010

Development stage
Preclinical
Lead developer
CStone Pharmaceuticals
Modality
Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

CS5010 is a next-generation antibody-drug conjugate (ADC) targeting the Human Epidermal Growth Factor Receptor 2 (HER2). Developed by CStone Pharmaceuticals, it is a key asset in their "Pipeline 2.0" program. The drug is distinguished by its dual-payload architecture, which utilizes a proprietary ADC platform and optimized linker technology to deliver two different cytotoxic agents selectively to HER2-expressing tumor cells. This approach is designed to enhance anti-tumor activity and potentially overcome resistance encountered with conventional single-payload ADCs. CS5010 is currently being investigated for the treatment of various solid tumors in the preclinical or early clinical development stages.

02

Targets

TUBB (Tubulin (alpha and beta subunits))TOP1 (DNA Topoisomerase I)ERBB2 (Erb-b2 receptor tyrosine kinase 2)

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