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CS5012
- Development stage
- Preclinical
- Lead developer
- CStone Pharmaceuticals
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
CS5012 is a preclinical-stage antibody-drug conjugate (ADC) developed by CStone Pharmaceuticals (formerly Cornerstone Pharmaceutical) that targets the human epidermal growth factor receptor 2 (HER2/erbB-2). The molecule is designed to treat HER2-expressing solid tumors, such as breast and gastric cancers, by utilizing a site-specific conjugation platform and a proprietary linker-payload system. This approach is intended to optimize the therapeutic index and overcome resistance mechanisms associated with existing HER2-targeted therapies. As of current development reports, CS5012 remains in the preclinical phase of investigation.
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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