CSF-1R siRNA

**CSF-1R siRNA** is an experimental **small interfering RNA** therapeutic designed to silence **colony-stimulating factor 1 receptor** expression, typically in tumor-associated macrophages, in order to disrupt CSF-1/CSF-1R signaling and shift macrophages from an immunosuppressive M2-like state toward a more inflammatory M1-like phenotype. In the provided literature context, it is not a named commercial or clinical-stage drug product but rather a research-use RNA payload incorporated into an **M2pep-modified cyclodextrin nanoparticle** delivery system for prostate cancer immunotherapy. The reported therapeutic rationale is tumor microenvironment remodeling, increased cytotoxic T-cell recruitment, and antitumor activity in preclinical mouse models.

Other names

colony stimulating factor 1 receptor small interfering RNAcolony-stimulating factor 1 receptor small interfering RNACSF-1R siRNACSF1R siRNACSF 1R siRNAcolony stimulating factor-1 receptor siRNAcolony-stimulating factor-1 receptor siRNA