Drug intelligence / Profile preview

csl760

Development stage
Discontinued
Lead developer
CSL Behring
Modality
Recombinant Proteins and Enzymes, Anti-infectious Disease mAbs → Neutralizing Antibodies → Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

CSL760 is a human hyperimmune product consisting of the purified gamma immunoglobulin (IgG) fraction of human plasma containing polyvalent neutralizing antibodies to SARS-CoV-2, the virus responsible for COVID-19. It was developed as an intravenous anti-SARS-CoV-2 hyperimmune globulin intended for passive immunotherapy in COVID-19 patients. The drug was being developed by CSL Behring, a subsidiary of CSL, and reached Phase 1 clinical trials before its development was discontinued. Its mechanism of action involves providing exogenous neutralizing antibodies to modulate immune response against SARS-CoV-2 infection[1][2][7].

02

Targets

SARS-CoV-2 spike

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