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CT-0729
- Development stage
- Preclinical
- Lead developer
- Carisma Therapeutics Inc
- Modality
- CAR-Macrophages → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
**CT-0729** is a preclinical, cell therapy drug consisting of engineered macrophages (CAR-M) designed to target **prostate-specific membrane antigen** (PSMA)[1][5]. The therapy uses chimeric antigen receptor macrophages specifically engineered to recognize and bind to PSMA, thereby inducing immunologic cytotoxicity against cancer cells expressing this antigen. Its primary development has focused on the treatment of metastatic castration-resistant prostate cancer[1][3]. The developer is **CTx Operations**, and the drug is associated with the class of targeted immunotherapies utilizing cell engineering to enhance anti-tumor responses.
- Other names
- CT-0729CT0729CT 0729PSMA targeted CAR-Macrophage
02
Targets
PSMA (Prostate-specific membrane antigen)
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