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CTB-Tim3 scFv-expressing Lactococcus lactis
- Development stage
- Preclinical
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Oral, Intranasal, Intragastric, Intravaginal, Intraperitoneal
01
Overview
CTB-Tim3 scFv-expressing Lactococcus lactis is an experimental live biotherapeutic product consisting of the food-grade bacterium *Lactococcus lactis* genetically engineered to express and secrete a fusion protein. This protein comprises a single-chain variable fragment (scFv) targeting T-cell immunoglobulin-3 (Tim-3) fused to the cholera toxin B subunit (CTB), which acts as a mucosal adjuvant and carrier. Tim-3 is an inhibitory immune checkpoint molecule that, when blocked, can revitalize exhausted T-cells and enhance anti-tumor immunity. Developed as a cost-effective alternative to traditional monoclonal antibodies, this microbial delivery system has demonstrated the ability to promote lymphocyte activation and inhibit tumor growth, proliferation, and angiogenesis in preclinical models of renal cell carcinoma.
- Other names
- Tim3scFv-Transforming LactobacillusTim-3scFv-Transforming LactobacillusTim 3scFv-Transforming LactobacillusTim3scFv-Transforming Lactococcus lactisTim-3scFv-Transforming Lactococcus lactisTim 3scFv-Transforming Lactococcus lactisNZ-CTB-Tim3scFvNZ-CTB-Tim-3scFvNZ-CTB-Tim 3scFv
02
Targets
HAVCR2 (T cell immunoglobulin and mucin domain-containing protein 3)
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