Drug intelligence / Profile preview

CTC-96

Development stage
Unknown
Lead developer
OPKO Health
Modality
DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
Administration
Topical, Ophthalmic
01

Overview

CTC-96 is a small molecule metallo-organic compound known as a cobalt(III) Schiff base chelate. It has demonstrated potent antiviral and anti-inflammatory properties in both in vitro and in vivo studies. The drug acts primarily by inhibiting free radicals and blocking essential enzymes required for viral replication. Mechanistically, it functions as an inhibitor of membrane fusion events during the life cycle of enveloped viruses, thereby preventing viral entry into host cells. CTC-96 has shown efficacy against herpes simplex virus (HSV), adenovirus type 5 (Ad5), varicella-zoster virus (VZV), and vesicular stomatitis virus (VSV). Its primary indications are infectious diseases affecting the eye—such as keratoconjunctivitis—and skin/musculoskeletal diseases[1][2][3][4][6][8].

Brand names
DoxovirDoxovir-L
Other names
cobalt chelate complex CTC-96Co(III) chelatemetallo-organic cobalt Schiff base complex
02

Targets

HMPV F (Human metapneumovirus fusion protein)

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