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cTfRMAb-GDNF
- Development stage
- Preclinical
- Lead developer
- JCR Pharmaceuticals
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**cTfRMAb-GDNF** is an investigational brain-penetrating recombinant fusion protein comprising human glial cell line-derived neurotrophic factor fused to the heavy chain of a chimeric monoclonal antibody against the mouse transferrin receptor. The anti-transferrin-receptor antibody domain acts as a blood-brain-barrier molecular Trojan horse, enabling receptor-mediated transcytosis after intravenous administration, while the GDNF domain activates GDNF trophic signaling in nigrostriatal dopaminergic pathways. In mouse 6-hydroxydopamine models of Parkinson's disease, systemic dosing improved behavioral and striatal tyrosine-hydroxylase measures; the construct was also evaluated in chronic mouse dosing studies. ([sciencedirect.com](https://www.sciencedirect.com/science/article/pii/S0090955624023249))
- Other names
- cTfRMAb-GDNFcTfRMAb-GDNF fusion protein
02
Targets
TFRC (Transferrin Receptor)GFRA1 (Glial cell line-derived neurotrophic factor family receptor alpha 1)
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