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Drug intelligence / Profile preview
CTLA-4 small-molecule chemical probe
- Development stage
- Preclinical
- Lead developer
- Baylor College of Medicine
- Modality
- Small Molecules
01
Overview
CTLA-4 small-molecule chemical probes are early-stage research tools designed to modulate the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) pathway. Developed by researchers at the Baylor College of Medicine, these small molecules target CTLA-4 or the interface of the CTLA-4/CD80 complex to provide a non-antibody approach to immune regulation. By avoiding the cellular degradation and antibody-dependent cellular cytotoxicity (ADCC) associated with monoclonal antibodies like ipilimumab, these probes aim to offer a safer and more tunable method for modulating immune tolerance. They are being investigated for potential applications in both cancer immunotherapy (to enhance T-cell activation) and autoimmune diseases (to heighten immunosuppression).
- Other names
- CTLA-4 small-molecule modulatorCTLA4 small-molecule modulatorCTLA 4 small-molecule modulatorsmall-molecule chemical probe targeting CTLA-4small-molecule CTLA-4 modulator
02
Targets
CD28 (Cluster of Differentiation 28)CD80 (T-lymphocyte activation antigen CD80)CD86 (T-lymphocyte activation antigen CD86)CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)
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