CTR1siRNA

CTR1siRNA is a small interfering RNA (siRNA) designed to silence the expression of the high affinity copper uptake protein 1 (CTR1), also known as SLC31A1. CTR1 is the primary transporter responsible for the influx of dietary copper into cells. In preclinical cardiovascular research, CTR1 has been identified as a mechanosensor in endothelial cells that responds to disturbed blood flow by promoting excessive copper uptake. This accumulation of copper leads to cuproptosis, a form of regulated cell death characterized by mitochondrial protein aggregation and respiratory dysfunction, which contributes to the development of atherosclerosis. By knocking down CTR1 expression, this siRNA prevents copper-mediated mitochondrial damage and has demonstrated the ability to reduce atherosclerotic lesions in animal models.

Other names

CTR1 siRNACTR-1 siRNACTR 1 siRNAsiRNA targeting CTR1