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ctrl-vax
- Development stage
- Unknown
- Lead developer
- University of Chicago
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intradermal
01
Overview
**ctrl-vax** is a preclinical control whole-cell melanoma vaccine used as the comparator for VEGF-C-expressing lymphangiogenic vaccine formulations. It consists of lethally irradiated, mock-transduced murine melanoma cells, including B16F10 or B16F10-OVA model cells depending on the experiment, administered with locally retained immune adjuvants. Unlike VEGFC-vax, ctrl-vax does not express vascular endothelial growth factor C and therefore does not deliberately induce local lymphangiogenesis. It was evaluated by University of Chicago investigators in intradermal mouse melanoma vaccination studies and generated weaker broad tumor-specific T-cell immunity and tumor protection than VEGFC-vax. ([aacrjournals.org](https://aacrjournals.org/cancerres/article/79/13_Supplement/1448/633487/Abstract-1448-Lymphangiogenesis-inducing-whole))
- Other names
- Ctrl vaxctrl-vax
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