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CTSS siRNA
- Development stage
- Preclinical
- Lead developer
- Taipei Medical University
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
CTSS siRNA is a small interfering RNA designed to silence the expression of Cathepsin S (CTSS), a lysosomal cysteine protease. In the context of head and neck cancer research, CTSS has been identified as a negative regulator of interleukin 7 (IL-7) secretion. By knocking down CTSS, the siRNA promotes the expression of the IL-7 receptor and subsequent IL-7 secretion, which enhances the proliferation and infiltration of activated CD8+ T cells within the tumor microenvironment. This approach aims to reverse the immune-suppressed state associated with high CTSS expression in cancers and is currently being explored in preclinical models.
- Other names
- cathepsin S siRNA
02
Targets
CTSS (Cathepsin S)AGO2 (Argonaute RISC catalytic component 2)
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