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CTX-4419

Development stage: Discontinued
Lead developer: Compass Therapeutics
Modality: Recombinant Proteins and Enzymes
Administration: Intravenous

Overview

CTX-4419 is a discontinued **biologic NK cell engager** developed by Compass Therapeutics for oncology, particularly **multiple myeloma**. It was designed as a **dual-function BCMA-targeting and NCR3-agonist molecule** intended to bind **B-cell maturation antigen** on malignant plasma cells while activating **natural cytotoxicity triggering receptor 3** on NK cells to promote NK-cell-mediated tumor killing. The program was positioned to address limitations associated with **CD16A polymorphism** that can affect some NK-cell-directed approaches, but its highest reported global R&D status is discontinued.

Targets

NCR3 (Natural cytotoxicity trigger receptor 3 (NKp30))FCGR3A (Low affinity immunoglobulin gamma Fc region receptor III-A)BCMA (B-cell maturation antigen)

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