Drug intelligence / Profile preview

cucurbita pepo extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Cucurbita pepo extract is derived from the seeds and sometimes other parts of the Cucurbita pepo plant, commonly known as pumpkin. It is used in traditional and herbal medicine for its potential effects on urinary tract and genital disorders, particularly benign prostatic hyperplasia (BPH), bladder irritation, and as an anthelmintic agent. The main active constituents include fatty oils, proteins, phytosterols (such as beta-sitosterol), tocopherols, cucurbitin (an amino acid with anthelmintic properties), and various antioxidants[1][3][5]. Clinical data are limited but suggest possible benefits for BPH symptoms; however, robust evidence is lacking. The mechanism of action may involve diuretic effects from increased urination due to phytochemicals in the seeds[6]. There are no well-documented severe adverse reactions or drug interactions except a possible interaction with lithium due to diuretic effects[6].

Brand names
IRK-19IRK19IRK 19
Other names
Pumpkin seed extractCucurbita semenPumpkin extractField pumpkin extract
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)NR1H3 (Liver X receptor beta)

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