Drug intelligence / Profile preview

cuet + icg

Development stage
Preclinical
Modality
Small Molecules
Administration
Topical, Intravenous
01

Overview

CuET + ICG is an experimental combination therapy that pairs **copper diethyldithiocarbamate (CuET)**, a bioactive copper complex, with **indocyanine green (ICG)**, a clinically approved near-infrared fluorescent dye. This formulation is explored for **photodynamic antimicrobial chemotherapy (PACT)**, leveraging ICG's ability to act as a photosensitizer, generating reactive oxygen species under laser/light exposure to kill bacteria, with CuET potentially enhancing antibacterial effects. The combination aims to improve sterilization and biofilm disruption against resistant pathogens, notably in diabetic foot infections. ICG is FDA-approved as a diagnostic agent for blood flow, hepatic, and ophthalmic assessment, but its use with CuET is investigational.

Other names
cuet + icg

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