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CURB906

Development stage
Unknown
Lead developer
Curative Biotechnology
Modality
Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Focal (direct) Intratumoral During Surgery
01

Overview

CURB906 is an investigational antibody-drug conjugate targeting CD56 (neural cell adhesion molecule 1) that is being developed for the treatment of glioblastoma and other CD56-expressing tumors. It consists of a fully humanized monoclonal antibody directed against CD56 conjugated to a cytotoxic payload, enabling selective delivery of the cytotoxic drug to the tumor site with the aim of killing tumor cells and inhibiting tumor growth and migration.[7][9][11][15][16] The program is being advanced by Curative Biotechnology (also referenced as Curative Biosciences) as a novel targeted therapy in neuro-oncology, with development currently at an early clinical or late preclinical stage for glioblastoma.[15][16]

Other names
CURB 906CURB906CURB-906
02

Targets

NCAM1 (Neural cell adhesion molecule 1)

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