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curcuma extract
- Development stage
- Unknown
- Lead developer
- Especialidades Farmacéuticas Centrum
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Curcuma extract (brand name: Extracto de Cúrcuma Centrum) is an oral botanical drug developed by Especialidades Farmacéuticas Centrum S.A. It is a standardized dry extract of the *Curcuma longa L.* rhizome, containing curcuminoids such as curcumin. While approved in Spain for the treatment of functional digestive disorders of hepatobiliary origin, it has been investigated in Phase IV clinical trials for moderate-to-severe plaque psoriasis. In the psoriasis context, it is used as a photosensitizer in combination with visible blue light phototherapy. Its mechanism of action involves the modulation of pro-inflammatory cytokine pathways, specifically inhibiting Interleukin-6 (IL-6) and Interleukin-8 (IL-8), and suppressing keratinocyte proliferation.
- Brand names
- Extracto de Cúrcuma Centrum
- Other names
- turmeric extractCurcuma longa extract
02
Targets
IL8 (C-X-C Motif Chemokine Ligand 8)IL-6 (Interleukin 6)
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