Drug intelligence / Profile preview

curcumagalactomannoside

Development stage
Preclinical
Lead developer
Akay Bioactives
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

**Curcumagalactomannoside** is a proprietary, food-grade curcumin formulation marketed as **CurQfen**. It is a water-dispersible, non-covalent complex of turmeric-derived curcuminoids with a fenugreek galactomannan dietary-fiber matrix, designed to increase systemic exposure to unconjugated free curcuminoids relative to conventional curcumin preparations. It was originated by Akay and is sold as a nutraceutical ingredient for oral dietary-supplement products. Human studies have evaluated it for knee osteoarthritis, occupational stress-related symptoms, safety, bioavailability, and other wellness-related outcomes; a six-week active-controlled knee-osteoarthritis study reported improvements in pain and function. In vitro, CGM induced ROS-associated mitochondrial apoptosis in HeLa cervical-cancer cells, but it is not an approved oncology therapy. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27043120/))

Brand names
CurQfen
Other names
CGMcurcumin-galactomannoside complexcurcumagalactomannosides
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)HDAC (HDAC family)LY96 (Myeloid differentiation factor 2)CREBBP (CREB-binding protein)

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