curcumenol

Curcumenol is a sesquiterpenoid compound and one of the major bioactive components of Zedoary turmeric oil (from Curcuma zedoaria and related Curcuma species)[1][2][9]. It has been reported to possess a range of biological activities including anti-inflammatory[1][2], neuroprotective[2][3], hepatoprotective[2], antibiotic/antibacterial (notably against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa)[9], and anticancer effects[7]. Mechanistically it inhibits NF-kappaB activation by suppressing nuclear translocation of the NF-kappaB p65 subunit and blocking IκBα phosphorylation/degradation; it also inhibits cytochrome P450 isoform CYP3A4 competitively in vitro but is not considered a mechanism-based inhibitor at clinically relevant concentrations[7]. Its main source is the rhizome of Curcuma zedoaria.

Other names

curcumenol(+)-curcumenol6H-3a,6-Epoxyazulen-6-ol, 1,2,3,4,5,8a-hexahydro-3,8-dimethyl-5-(1-methylethylidene)-, (3S-(3-alpha,3a-alpha,6-alpha,8a-beta))5-beta-guiaia-7(11),9-dien-8-alpha‑ol, 5,8‑epoxy-(1S,2S,5S,8R)-2,6-dimethyl‑9-propan‑2‑ylidene‑11‑oxatricyclo[6.2.1.01 ,5]undec‑6-en‑8–ol