Drug intelligence / Profile preview

curcumin + coenzyme q10

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Curcumin + coenzyme Q10 is a fixed-dose combination dietary supplement containing two bioactive compounds—curcumin (the principal curcuminoid of turmeric) and coenzyme Q10 (ubiquinone). Curcumin is known for its anti-inflammatory, antioxidant, and potential lipid-lowering properties. It acts by inhibiting cyclooxygenase 2 (COX-2), modulating inflammatory pathways, and scavenging free radicals. However, its clinical utility is limited by low oral bioavailability due to rapid metabolism. Coenzyme Q10 is a mitochondrial electron transport chain component with antioxidant activity; it supports cellular energy production and may reduce oxidative stress. The combination aims to synergistically enhance anti-inflammatory effects, improve mitochondrial function, support cardiovascular health (including cholesterol management), reduce migraine severity/frequency in some studies, and potentially provide neuroprotective benefits[1][2][4][5][6]. Formulations often include excipients like phospholipids or medium-chain triglycerides to improve absorption.

Brand names
Curcumin Co-Q10
Other names
curcumin and coenzyme Q10curcumin plus coenzyme Q10turmeric extract and CoQ10nano-curcumin and CoQ10
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)bc1 complex (Cytochrome bc1 complex (plasmodium))

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