curcumin + simvastatin

curcumin + simvastatin is a combination pharmacological treatment being evaluated for the management of periodontal defects. It consists of simvastatin, a chemical modification of lovastatin that acts as an HMG-CoA reductase inhibitor, and curcumin, the primary active constituent of turmeric. Simvastatin is included for its anti-inflammatory effects and its ability to inhibit bone resorption while stimulating bone formation. Curcumin provides complementary anti-inflammatory, antioxidant, and antimicrobial properties, targeting both the bacterial pathogens and the host's inflammatory response. This combination is typically formulated as a paste for local application following procedures such as EDTA root surface etching and open flap debridement in patients with stage II-III periodontitis.

Other names

curcumin simvastatin pastecurcumin-simvastatin pastecurcumin-simvastatin combination