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curcumin + zinc
- Development stage
- Unknown
- Lead developer
- ProbioticsSmart
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Oral
01
Overview
Curcumin + zinc refers to molecular complexes and co-delivery systems designed to enhance the therapeutic potential of the polyphenolic compound curcumin by complexing it with the essential mineral zinc. A prominent commercial form is TurmiZn-OS, a proprietary molecular complex where zinc forms a covalent bond with curcumin and tetrahydrocurcumin to significantly improve aqueous solubility, stability, and bioavailability compared to standard curcumin. These complexes exert multi-faceted biological effects, including potent antioxidant and anti-inflammatory activities, and the modulation of key signaling pathways such as PI3K/AKT/mTOR and MAPK. Emerging research also highlights their role in promoting mitophagy via the PINK1/Parkin pathway, offering neuroprotective potential. They are primarily developed as nutraceuticals for managing prediabetes, diabetes, inflammatory conditions, and neurodegenerative disorders like Parkinson's disease.
- Brand names
- TurmiZn-OSTurmiZn
- Other names
- zinc-curcumin complexSPI-curcumin-zinc ternary nanocomplexcurcumin-zinc co-delivery
02
Targets
PINK1 (PTEN-induced kinase 1)PRKN (E3 ubiquitin-protein ligase parkin)
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