Drug intelligence / Profile preview

Curcumin C3 Complex

Development stage
Unknown
Lead developer
Sabinsa
Modality
Small Molecules
Administration
Oral
01

Overview

Curcumin C3 Complex is a patented, standardized extract of curcuminoids derived from the rhizomes of *Curcuma longa* (turmeric). It contains a minimum of 95% curcuminoids, specifically curcumin (diferuloylmethane), demethoxycurcumin, and bisdemethoxycurcumin. This specific formulation was investigated by Dr. Nita Chainani-Wu at the University of California, San Francisco, for the treatment of oral lichen planus (OLP), a chronic inflammatory autoimmune condition. The treatment aims to reduce mucosal inflammation and associated symptoms by modulating pro-inflammatory markers such as interleukin-6 (IL-6) and C-reactive protein (CRP). Clinical trials have evaluated doses ranging from 2000 mg/day to 6000 mg/day, with the higher dose showing efficacy in controlling OLP signs and symptoms.

Brand names
Curcumin C3 Complex
Other names
curcuminoidscurcumindemethoxycurcuminbisdemethoxycurcumin
02

Targets

PKC (Protein kinase C family)TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)

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