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curcumin sterically stabilized micelles
- Development stage
- Preclinical
- Lead developer
- University of Illinois Chicago
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous, Parenteral
01
Overview
C-SSM (curcumin sterically stabilized micelles) is a nanomicellar formulation of curcumin encapsulated in sterically stabilized phospholipid micelles. Developed by researchers at the University of Illinois at Chicago, C-SSM is designed to overcome the poor aqueous solubility, instability, and low bioavailability of free curcumin. By encapsulating curcumin in PEGylated phospholipid micelles (such as DSPE-PEG), the formulation enhances the stability and cellular uptake of curcumin. C-SSM has been investigated in preclinical studies for its anti-cancer activity, particularly in targeting breast cancer and breast cancer stem cells (CSCs), where it inhibits tumorsphere formation and suppresses key self-renewal pathways.
- Other names
- curcumin in sterically stabilized phospholipid micellesnanomicellar curcuminsterically stabilized curcumin phospholipid nanomicelles
02
Targets
DNMT1 (DNA (cytosine-5)-methyltransferase 1)DYRK2 (Dual-specificity tyrosine-phosphorylation-regulated kinase 2)TXNRD1 (Thioredoxin reductase 1)
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