Drug intelligence / Profile preview

Curcuminoid Standardized Turmeric Capsules

Development stage
Phase 3
Lead developer
Universitas Gadjah Mada
Modality
Small Molecules
Administration
Oral
01

Overview

Curcuminoid Standardized Turmeric Capsules are an investigational natural product formulation developed by Gadjah Mada University for the treatment of knee osteoarthritis. The capsules contain a standardized extract of turmeric (Curcuma domestica Val. or Curcuma longa) providing 30 mg of curcuminoids per dose. Curcuminoids are polyphenolic compounds known for their anti-inflammatory properties. The mechanism of action involves the modulation of various inflammatory mediators, including the inhibition of cyclooxygenase-2 (COX-2) and the reduction of pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP). Clinical research at Gadjah Mada University has focused on evaluating the efficacy of these capsules in reducing pain and improving inflammatory biomarkers in patients with osteoarthritis genu.

Other names
Curcuminoid standardized turmeric extractCurcuminoids (Gadjah Mada University)
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)

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