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curcuminoids + N-acetylcysteine + deferiprone + vitamin E

Development stage
Unknown
Lead developer
Nita Chainani Wu
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
Administration
Oral
01

Overview

This is a combination product containing four active ingredients: - **Curcuminoids** are polyphenolic compounds derived from turmeric, known for their antioxidant and anti-inflammatory properties. - **N-acetylcysteine (NAC)** is an acetylated variant of the amino acid L-cysteine, used as an antioxidant and mucolytic agent. It increases glutathione levels in the body and is clinically used to treat acetaminophen overdose by binding toxic metabolites[1][2][3][4]. - **Deferiprone** is an oral iron chelator that binds excess iron in the body, facilitating its excretion. It is primarily indicated for treating iron overload due to blood transfusions in conditions like thalassemia syndromes and sickle cell disease[6][8][10]. - **Vitamin E** refers to a group of fat-soluble antioxidants that protect cell membranes from oxidative damage. The combination aims to provide synergistic antioxidant effects (curcuminoids, NAC, vitamin E), support detoxification (NAC), reduce oxidative stress (all components), and manage metal overload through chelation (deferiprone). There are no widely recognized brand or code names for this specific four-drug combination; it may be formulated as a dietary supplement or experimental therapy.

Other names
Antioxidant Cocktail
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ROS (Reactive oxygen species and electrophilic radicals)NEMO (NF-κB essential modulator)GCL (Gamma-glutamylcysteine Synthetase)NOS2 (Nitric Oxide Synthase 2)

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