Drug intelligence / Profile preview

Curcuminoids C3 Complex

Development stage
Phase 2
Lead developer
Sabinsa
Modality
Small Molecules
Administration
Oral
01

Overview

Curcuminoids C3 Complex is a patented, standardized extract derived from the rhizome of turmeric (Curcuma longa), containing a defined mixture of three major curcuminoids: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. It is formulated to contain 95% total curcuminoids and is often combined with BioPerine (piperine) to enhance absorption and bioavailability[1][4]. The primary mechanisms of action are antioxidant activity—scavenging free radicals—and anti-inflammatory effects through inhibition of cyclooxygenase (COX) and lipoxygenase (LOX) enzymes involved in the arachidonic acid pathway[4]. Preclinical studies show antineoplastic activity via induction of apoptosis in cancer cells[2], while clinical trials suggest benefits for joint health, physical function in older adults with low-grade inflammation, support for liver health, and potential improvement in chronic plaque psoriasis[5][6][8]. Developed by Sabinsa Corporation as a dietary supplement ingredient.

Brand names
Curcumin C3 Complex
Other names
Curcuminoid C3 ComplexCurcumin-C3complexCurcumin-C-3complexCurcumin-C 3complexCurcumin C3 complex
02

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)NF-κBEGFR T790M (Epidermal growth factor receptor T790M mutant)TP53 (Cellular Tumor Antigen p53 R175H)15-LOX (Lysyl Oxidase)

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