curdepsidone A

Curdepsidone A is a natural depsidone isolated from the marine-derived endophytic fungus Curvularia sp. IFB-Z10. It exhibits potent anti-tumor activity, particularly against human cervical cancer cells (HeLa), where it induces G0/G1 phase cell cycle arrest and promotes apoptosis through the mitochondrial pathway. Its mechanism involves inhibition of protective autophagy, elevation of intracellular reactive oxygen species (ROS), and suppression of PI3K/AKT signaling. These combined actions lead to anti-proliferative and pro-apoptotic effects in various tumor cell lines, with the greatest sensitivity seen in HeLa cells. Structure revision and mechanistic studies suggest potential for development as a chemotherapy agent for cervical cancer[1][3][5][4].

Other names

2,7-dihydroxy-9-methoxy-4,10-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-8-carboxylic acid