Drug intelligence / Profile preview

Curenext

Development stage
Phase 4
Lead developer
Tatyasaheb Kore Dental College & Research Centre
Modality
Small Molecules
Administration
Topical
01

Overview

Curenext is a topical gel formulation containing curcumin, the primary bioactive polyphenol extracted from turmeric (*Curcuma longa*). Developed as an adjunctive treatment for chronic periodontitis, it is applied to periodontal pockets following scaling and root planing (SRP). Curcumin exhibits a multi-faceted mechanism of action, including potent antioxidant properties that neutralize reactive oxygen species (ROS), anti-inflammatory effects through the inhibition of NF-kappaB and COX-2 pathways, and broad-spectrum antibacterial activity. By reducing oxidative stress and modulating the host immune response, Curenext helps to limit tissue destruction and promote periodontal healing.

Brand names
Curenext
Other names
Curcuma longa gelcurcumin gel
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)IL1B (Interleukin-1 beta)MMP12 (Macrophage Metalloelastase)NF-κBTNFA (Tumor necrosis factor alpha (soluble))

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