cvd 1902

CVD 1902 is a live attenuated oral vaccine candidate against Salmonella enterica serovar Paratyphi A (S. Paratyphi A), which causes paratyphoid fever. It was constructed from wild-type parent strain S. Paratyphi A strain ATCC 9150 by deleting the guaBA chromosomal operon (involved in guanine nucleotide biosynthesis) and the clpX gene (encoding a chaperone ATPase). The clpX mutation results in hyperexpression of flagella and serves as a second attenuating mutation to minimize the risk of reversion to full virulence. The vaccine is designed to stimulate both local protective immune responses along the intestinal surface and systemic immunity.

Other names

Salmonella Paratyphi A vaccinelive attenuated S. Paratyphi A vaccineParatyphoid vaccineS. Paratyphi Vaccine