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CVD1

Development stage: Unknown
Lead developer: Sirius Therapeutics
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics

Overview

CVD1 is an investigational small interfering RNA (siRNA) therapy being developed by Sirius Therapeutics (also known as Sirius Natural) for the treatment of cardiovascular disease (CVD). As part of Sirius's proprietary siRNA platform, the drug is designed to achieve gene silencing of an undisclosed target relevant to cardiovascular pathology. The company utilizes specialized delivery technology to target tissues such as the liver, adipose tissue, heart, kidney, or central nervous system (CNS). CVD1 is currently in Phase 1 clinical development, with the initial study expected to complete by 2028.

Targets

F11 (Coagulation Factor XI)

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